Cajun Tilapia Sandwich with Cilantro Lime Mayonnaise

February 15, 2018

This Tilapia sandwich is a quick and easy recipe that your family is sure to enjoy!

  • Prep: 35 mins
  • Cook: 20 mins


For the Cajun Spice Blend:

3/4 tsp salt

2 tsp garlic powder

2 tsp smoked paprika

1 tsp onion powder

1 tsp dried oregano

1 tsp dried thyme

3/4 tsp cayenne pepper

For the Cilantro-Lime Mayonnaise:

2 tbsp mayonnaise

2 tbsp 2% Greek yogurt

1 tbsp lime juice

2 tsp minced fresh cilantro

For the fish:

1/2 tbsp cajun spice blend

4 Tilapia filets

4 slices of bacon

1 medium tomato - sliced

4 leaves of romaine or butter lettuce

4 hamburger buns


1In a small bowl, whisk together the mayonnaise, yogurt, lime juice and cilantro. Cover and refrigerate until ready to assemble the sandwiches.

2Make the spice blend: Mix all spices/herbs together until blended.

3Heat a large fry pan over medium heat and cook bacon until crisp. Remove the bacon from the pan, transfer to a paper towel-lined plate, and leave 1 tablespoon of bacon grease to the hot pan to cook the fish.

4Coat both sides of each tilapia filet generously with the cajun spice blend, pressing gently to coat. Put the coated filets on a plate while you make the bacon.

5Add as many of the filets to the hot pan as can fit, and cook until the underside is crisp and browned, 3 minutes. Gently flip the filets and cook for 3 more minutes. Remove the filets to a clean plate.

6Assemble the sandwiches by laying the hamburger buns on a clean work surface and smearing 1 tablespoon cilantro-lime mayo on the (face-up) top sides of each. On the bottom halves, layer a leaf of romaine, 2 to 3 slices of avocado, 1 tilapia filet, and 1 slice of bacon (folded in half or cut in half to cover more area). Top with the mayo-smeared halves and serve immediately.



Nutrition Facts

Serving Size1 Sandwich
Total Fat16.8g

4 Reviews

Bill Schutz

November 17, 2019

I tweeted this a little (old bay instead of Cajun) and I LOVED IT! I also used Kings Hawaiian sandwich buns. Yummy will make again.

Teresa Deliz

August 19, 2019

Really delicious! Especially on Puerto Rican pan Sobao. The avocado in the sandwich gives it a little something extra. Will make this again!

Josh Estrin

August 12, 2019

Hi Christina –

Several of us here are Keto and we always make adjustments. Clearly, keep your macros in mind and bread well that goes without saying – but increase the fat with healthy oils etc and decrease those carbs ! We will be posting several lower carb and Keto-friendly recipes very soon!

Christina Alexander

July 31, 2019

I wonder if this can be done low carb or Keto diet style

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